1·A lack of qualifications can be a major obstacle to finding a job.
学历不足可能成为谋职的主要障碍。
—— 《牛津词典》
2·What if there is a major obstacle standing in your way?
如果你的路上有一块巨大的障碍物，那怎么办呢？
3·It has become a major obstacle to use forum data effectively.
这一问题已经成为有效利用论坛数据的一个主要障碍。
4·Localism is a major obstacle to the integration of the Americas.
地方主义，是美洲一体化的最大阻碍。
5·What was a major obstacle you were able to overcome in the past year?
你在过去的一年里克服了什么重要的障碍？
6·Getting the right cells to pair up before fusing them is one major obstacle.
在将细胞融合之前将他们正确配对是一个主要障碍。
7·MOTIVATION: Protein insolubility is a major obstacle for many experimental studies.
动机：蛋白质不溶性是很多实验研究的主要障碍。
8·The resistance of tumor cells to drugs is a major obstacle to effective cancer chemotherapy.
肿瘤细胞对化疗药物的耐药性是癌症化疗中的主要难题。
9·The major obstacle to attaining a molecular composite, however , is the homogenous miscibility.
制备分子复合材料的关键在于溶混性。
10·The major obstacle in development it's to make a structured design that allows the reuse of parts.
开发中的主要障碍是要使用结构化设计以提供组件的重用。